Addition reactions
3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.
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- Henry reaction (nitroaldol addition)Additionnitroaldol Base-catalysed addition of a nitroalkane to an aldehyde to give a β-nitro alcohol that dehydrates under Knoevenagel-Henry conditions to the conjugated nitroalkene. Scale
- Kharasch additionAddition The Kharasch addition is an organic reaction and a metal-catalysed free radical addition of CXCl3 compounds (X = Cl, Br, H) to alkenes.
- Mannich reactionAddition In organic chemistry, the Mannich reaction is a three-component organic reaction that involves the amino alkylation of the α-position of a ketone or aldehyde with an aldehyde and a nullary, primary, or secondary amine (−NH2).
- Michael addition reactionAddition In organic chemistry, the Michael reaction or Michael 1,4 addition is a reaction between a Michael donor (an enolate or other nucleophile) and a Michael acceptor (usually an α,β-unsaturated carbonyl) to produce a Michael adduct by creating a carbon-carbon bond at the acceptor's β-carbon.
- Michaelis–Arbuzov reactionAddition The Michaelis–Arbuzov reaction (also called the Arbuzov reaction) is the chemical reaction of a trivalent phosphorus ester with an alkyl halide to form a pentavalent phosphorus species and another alkyl halide.
- Michaelis–Becker reactionAddition The Michaelis–Becker reaction is the reaction of a hydrogen (thio)phosphonate with a base, followed by a nucleophilic substitution of phosphorus on a haloalkane, to give an alkyl (thio)phosphonate.
- Nitro-Mannich reactionAddition The nitro-Mannich reaction (or aza-Henry reaction) is the nucleophilic addition of a nitroalkane (or the corresponding nitronate anion) to an imine, resulting in the formation of a beta-nitroamine.
- 1,2-Addition of a functionalized zinc-copper organometallic [RCu(CN)ZnI] to an α,β-unsaturated aldehyde: (E)-2-(4-hydroxy-6-phenyl-5-hexenyl)-1H-isoindole-1,3(2H)-dioneAddition
- Addition of an ethylcopper complex to 1-octyne: (E)-5-ethyl-1,4-undecadieneAddition
- Addition of dialkylamines to myrcene: N,N-diethylgeranylamineAddition
- Addition of organolithium reagents to allyl alcohol: 2-methyl-1-hexanolAddition
- Aprotic double Michael addition: 1,3-dimethyl-5-oxobicyclo[2.2.2]octane-2-carboxylic acidAddition
- Asymmetric hydroboration of 5-substituted cyclopentadienes: synthesis of methyl (1 R,5R)-5-hydroxy-2-cyclopentene-1-acetateAddition
- Benzyl isopropoxymethyl carbamate - an aminomethylating reagent for Mannich reactions of titanium enolatesAddition
- Catalytic asymmetric addition of an in-situ prepared arylzinc to cyclohexanecarboxaldehyde: (R)-(+)-α-cyclohexyl-3-methoxy-benzenemethanolAddition
- Catalytic enantioselective addition of dialkylzincs to aldehydes using (2S)-(−)-3-exo-(dimethylamino)isoborneol [(2S)-DAIB]: (S)-1-phenyl-1-propanolAddition
- Catalytic enantioselective addition of terminal alkynes to aldehydes: preparation of (S)-(-)-1,3-diphenyl-2-propyn-1-ol and (S)-(-)-4-methyl-1-phenyl-2-pentyn-1,4-diolAddition
- Conjugate addition of a vinylzirconium reagent: 3-(1-octen-1-yl)cyclopentanoneAddition
- Copper-catalyzed conjugate addition of a zinc homoenolate: ethyl 3-[3-(trimethylsilyloxy)cyclohex-2-enyl]propionateAddition
- Copper-catalyzed conjugate addition of functionalized organozinc reagents to α,β-unsaturated ketones: ethyl 5-(3-oxocyclohexyl)pentanoateAddition
- Copper(I) iodide dimethyl sulfide catalyzed addition of a vinylzirconium reagent (preparation of 4-phenyl-5(E)-decen-2-one)Addition
- Cyanide-catalyzed conjugate addition of aryl aldehydes: 4-oxo-4-(3-pyridyl)butyronitrileAddition
- Diels-Alder addition of perchlorobenzyne: benzobarreleneAddition
- Diethylaminotrimethylsilane-catalyzed 1,4-addition of aldehydes to vinyl ketones: (3R)-3,7-dimethyl-2-(3-oxobutyl)-6-octenalAddition
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