Mannich reaction
Named reactionAddition
In organic chemistry, the Mannich reaction is a three-component organic reaction that involves the amino alkylation of the α-position of a ketone or aldehyde with an aldehyde and a nullary, primary, or secondary amine (−NH2). The final product is a β-amino-carbonyl compound also known as a Mannich base. The reaction is named after Carl Mannich.
Checked procedures in Organic Syntheses
- Benzyl isopropoxymethyl carbamate - an aminomethylating reagent for Mannich reactions of titanium enolates
- Regioselective Mannich condensation with dimethyl(methylene)ammonium trifluoroacetate: 1-(dimethylamino)-4-methyl-3-pentanone
- Synthesis of tert-butyl (1S,2S)-2-methyl-3-oxo-1-phenylpropylcarbamate by asymmetric Mannich reaction