Catalytic enantioselective addition of dialkylzincs to aldehydes using (2S)-(−)-3-exo-(dimethylamino)isoborneol [(2S)-DAIB]: (S)-1-phenyl-1-propanol
CAS index name: Benzenemethanol, α-ethyl-, (S)-
Organic SynthesesAddition
A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.
Reagents
| Compound | Role | Equiv | MW (g/mol) | ρ (g/mL) | Safety |
|---|---|---|---|---|---|
| (S)-1-Phenylpropanol613-87-6 · C9H12O | product | — | 136.19 | — | Warning |
More addition reactions
- 1,2-Addition of a functionalized zinc-copper organometallic [RCu(CN)ZnI] to an α,β-unsaturated aldehyde: (E)-2-(4-hydroxy-6-phenyl-5-hexenyl)-1H-isoindole-1,3(2H)-dione
- Addition of an ethylcopper complex to 1-octyne: (E)-5-ethyl-1,4-undecadiene
- Addition of dialkylamines to myrcene: N,N-diethylgeranylamine
- Addition of organolithium reagents to allyl alcohol: 2-methyl-1-hexanol
- Aprotic double Michael addition: 1,3-dimethyl-5-oxobicyclo[2.2.2]octane-2-carboxylic acid
- Asymmetric hydroboration of 5-substituted cyclopentadienes: synthesis of methyl (1 R,5R)-5-hydroxy-2-cyclopentene-1-acetate