Reactions · Wikipedia: Category:Name reactions ↗
Williamson ether synthesis
Substitution
SN2
Overview
The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and a deprotonated alcohol (alkoxide). This reaction was developed by Alexander Williamson in 1850. Typically it involves the reaction of an alkoxide ion with a primary alkyl halide via an SN2 reaction. This reaction is important in the history of organic chemistry because it helped prove the structure of ethers.
Actions
- This entry doesn't have stoichiometric equivalents on file yet — the Reaction Scale Calculator needs at least one participant tagged with an equivalents value.
- Mechanism / source ↗
- View as JSON ↗
Search literature
More Substitution reactions
- A GENERAL PROCEDURE FOR MITSUNOBU INVERSION OF STERICALLY HINDERED ALCOHOLS: INVERSION OF MENTHOL. (1S,2S,5R)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL 4-NITROBENZOATE (Cyclohexanol, 5-methyl-2-(1-methylethyl)-, 4-nitrobenzoate, [1S-(1α,2α,5β)]-) Substitution
- Appel reaction Substitution
- Catalytic Intramolecular Friedel-Crafts Reaction of Benzyl Meldrum's Acid Derivatives: Preparation of 5,6-Dimethoxy-2-Methyl-1-Indanone Electrophilic aromatic substitution
- Finkelstein reaction Substitution
- Friedel-Crafts acylation: benzene + acetyl chloride → acetophenone Electrophilic aromatic substitution
- Indium-Catalyzed Heteroaryl–Heteroaryl Bond Formation through Nucleophilic Aromatic Substitution: Preparation of 2-Methyl-3-(thien-2-yl)-1H-indole Substitution