Drug-Likeness Calculator
Evaluate Lipinski Rule of 5, Veber rules, and lead-likeness from a SMILES string.
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Lipinski
Veber
Lead-like
MW
LogP
HBD
HBA
TPSA
RotB
Rings
Fsp3
| Rule | Value | Status |
|---|
About Drug-Likeness Rules
Lipinski's Rule of 5 predicts that poor absorption or permeation is more likely when: MW > 500, LogP > 5, HBD > 5, or HBA > 10. A compound can have at most 1 violation and still be considered drug-like.
Veber Rules predict oral bioavailability based on: rotatable bonds ≤ 10 and TPSA ≤ 140 Ų.
Lead-likeness defines a more restrictive chemical space for lead optimization: MW ≤ 350, LogP ≤ 3.5, rotatable bonds ≤ 7.