Asymmetric hydrogenation of 3-oxo carboxylates using BINAP-ruthenium complexes: (R)-(−)-methyl 3-hydroxybutanoate

CAS index name: Butanoic acid, 3-hydroxy-, methyl ester, (R)-

Organic SynthesesReduction

Reaction scheme of Asymmetric hydrogenation of 3-oxo carboxylates using BINAP-ruthenium complexes: (R)-(−)-methyl 3-hydroxybutanoate from Organic Syntheses
Scheme as published in Org. Synth. Coll. Vol. 9, p. 589; Vol. 71, p. 1.

A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.

Reagents

CompoundRoleEquivMW (g/mol)ρ (g/mL)Safety
Methyl (-)-3-hydroxybutyrate3976-69-0 · C5H10O3 product — 118.13 — Corrosive (GHS05)Irritant (GHS07)Danger

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