Reduction of alkyl halides and tosylates with sodium cyanoborohydride in hexamethylphosphoric triamide (HMPA):A. 1-Iododecane to n-decaneb. 1-Dodecyl tosylate to n-dodecane
Organic SynthesesReduction
A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.
Reagents
| Compound | Role | Equiv | MW (g/mol) | ρ (g/mL) | Safety |
|---|---|---|---|---|---|
| Hexamethylphosphoramide680-31-9 · C6H18N3OP | product | — | 179.20 | 1.030 | Danger |
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- Apparatus for catalytic reduction