Preparation of enantiomerically enriched (1S)-1-phenylpropan-1-amine hydrochloride by a catalytic addition of diorganozinc reagents to imines
CAS index name: Benzenemethanamine, α-ethyl-, hydrochloride, (αS)-
Organic SynthesesAddition
A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.
Reagents
The compound this preparation makes is not in the catalogue, so no reagents or figures are listed here.
More addition reactions
- 1,2-Addition of a functionalized zinc-copper organometallic [RCu(CN)ZnI] to an α,β-unsaturated aldehyde: (E)-2-(4-hydroxy-6-phenyl-5-hexenyl)-1H-isoindole-1,3(2H)-dione
- Addition of an ethylcopper complex to 1-octyne: (E)-5-ethyl-1,4-undecadiene
- Addition of dialkylamines to myrcene: N,N-diethylgeranylamine
- Addition of organolithium reagents to allyl alcohol: 2-methyl-1-hexanol
- Aprotic double Michael addition: 1,3-dimethyl-5-oxobicyclo[2.2.2]octane-2-carboxylic acid
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