chempirical
Reaction database

Cyclization reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

1–24 of 44

  1. Allan–Robinson reactionCyclization The Allan–Robinson reaction is the chemical reaction of o-hydroxyaryl ketones with aromatic anhydrides to form flavones (or isoflavones). Named reaction · Wikipedia
  2. Bergman cyclizationCyclization The Masamune-Bergman cyclization or Masamune-Bergman reaction or Masamune-Bergman cycloaromatization is an organic reaction and more specifically a rearrangement reaction taking place when an enediyne is heated in presence of a suitable hydrogen donor (Scheme 1). Named reaction · Wikipedia
  3. Borsche–Drechsel cyclizationCyclization The Borsche–Drechsel cyclization is a chemical reaction used to synthesize tetrahydrocarbazoles by the acid-catalyzed cyclization of cyclohexanone arylhydrazones. Named reaction · Wikipedia
  4. Danheiser annulationCyclization The Danheiser annulation or Danheiser TMS-cyclopentene annulation is an organic reaction of an α,β-unsaturated ketone and a trialkylsilylallene (e.g., trimethylsilyl- or triisopropylsilyl-) in the presence of a Lewis Acid to give a trialkylsilylcyclopentene in a regiocontrolled annulation. Named reaction · Wikipedia
  5. Danheiser benzannulationCyclization The Danheiser benzannulation is a chemical reaction used in organic chemistry to generate highly substituted phenols in a single step. Named reaction · Wikipedia
  6. Ferrier carbocyclizationCyclization The Ferrier carbocyclization (or Ferrier II reaction) is an organic reaction that was first reported by the carbohydrate chemist Robert J. Ferrier in 1979. Named reaction · Wikipedia
  7. Nazarov cyclizationCyclization The Nazarov cyclization, also known as the Nazarov reaction, is a chemical reaction used in organic chemistry for the synthesis of cyclopentenones. Named reaction · Wikipedia
  8. Pschorr cyclizationCyclization The Pschorr cyclization is a name reaction in organic chemistry, which was named after its discoverer, the German chemist Robert Pschorr (1868-1930). Named reaction · Wikipedia
  9. Robinson annulationCyclization The Robinson annulation is a chemical reaction used in organic chemistry for ring formation. Named reaction · Wikipedia
  10. Robinson–Gabriel synthesisCyclization The Robinson–Gabriel synthesis is an organic reaction in which a 2-acylamino-ketone reacts intramolecularly followed by a dehydration to give an oxazole. Named reaction · Wikipedia
  11. Volhard–Erdmann cyclizationCyclization The Volhard–Erdmann cyclization is an organic synthesis of alkyl and aryl thiophenes by cyclization of disodium succinate or other 1,4-difunctional compounds (γ-oxo acids, 1,4-diketones, chloroacetyl-substituted esters) with phosphorus heptasulfide. Named reaction · Wikipedia
  12. [3+2]-Anionic electrocyclization using 2,3-bis(phenylsulfonyl)-1,3-butadiene: trans-4,7,7-tricarbomethoxy-2-phenylsulfonylbicyclo[3.3.0]oct-1-eneCyclization Org. Synth. Coll. Vol. 9, p. 82; Vol. 74, p. 147 · Padwa et al.
  13. [3 + 4] Annulation using a [β-(trimethylsilyl)acryloyl]silane and the lithium enolate of an α,β-unsaturated methyl ketone: (1R,6S,7S)-4-(tert-butyldimethylsiloxy)-6-(trimethylsilyl)bicyclo[5.4.0]undec-4-en-2-oneCyclization Org. Synth. Vol. 76, p. 199 · Takeda et al.
  14. (E)-1-Benzyl-3-(1-iodoethylidene)piperidine: nucleophile-promoted alkyne-iminium ion cyclizationsCyclization Org. Synth. Coll. Vol. 9, p. 46; Vol. 70, p. 111 · Arnold et al.
  15. Conjugate addition–cyclization of a cyanocuprate: 2-carbomethoxy-3-vinylcyclopentanoneCyclization Org. Synth. Coll. Vol. 8, p. 112; Vol. 66, p. 52 · Nugent and Hobbs
  16. Cyclobutanone via solvolytic cyclizationCyclization Org. Synth. Coll. Vol. 6, p. 324; Vol. 54, p. 84 · Hanack et al.
  17. Cyclopentadiene annulation via the Skattebøl rearrangement: (1R)-9,9-dimethyltricyclo-[6.1.1.02,6]deca-2,5-dieneCyclization Org. Synth. Coll. Vol. 8, p. 223; Vol. 68, p. 220 · Paquette and McLaughlin
  18. Cyclopentanone annulation via cyclopropanone derivatives: (3aβ,9bβ)-1,2,3a,4,5,9b-hexahydro-9b-hydroxy-3a-methyl-3H-benz[e]inden-3-oneCyclization Org. Synth. Coll. Vol. 9, p. 466; Vol. 74, p. 137 · Bradlee and Helquist
  19. Diazo ketone cyclization onto a benzene ring: 3,4-dihydro-1(2H)-azulenoneCyclization Org. Synth. Coll. Vol. 8, p. 196; Vol. 69, p. 180 · Scott and Sumpter
  20. Discussion Addendum for: [3 + 4] Annulation Using a [ß-(Trimethylsilyl) acryloyl]silane and the Lithium Enolate of an a,ß-Unsaturated Methyl Ketone: (1R,6S,7S)-4-(tert-Butyldimethylsiloxy)-6-(trimethylsilyl)bicyclo [5.4.0]undec-4-en-2-oneCyclization Org. Synth. Vol. 89, p. 267 · Takeda* and Sasaki
  21. Discussion Addendum for: 5-endo-trig cyclization of 1,1-difluoro-1-alkenes: synthesis of 3-butyl-2-fluoro-1-tosylindole (1H-indole, 3-butyl-2-fluoro-1-[(4-methylphenyl)sulfonyl]-)Cyclization Org. Synth. Vol. 88, p. 162 · Ichikawa.*
  22. Discussion Addendum for: synthesis of indoles by palladium catalyzed reductive N-heteroannulation of 2-nitrostyrenes: methyl indole-4-carboxylateCyclization Org. Synth. Vol. 88, p. 291 · Söderberg.*
  23. Electrophilic cyclization with N-iodosuccinimide: preparation of 5-(4-bromophenyl)-3-iodo-2-(4-methyl-phenyl)furanCyclization Org. Synth. Vol. 84, p. 199 · Sniady et al.
  24. Fragmentation-recombination Nazarov cyclization: 3,4-dimethylcyclopent-2-en-1-oneCyclization Org. Synth. Vol. 83, p. 49 · Schwartz and White