Reaction database

Substitution reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

1–5 of 5

  1. A general procedure for Mitsunobu inversion of sterically hindered alcohols: inversion of menthol. (1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl 4-nitrobenzoateSubstitution Org. Synth. Coll. Vol. 9, p. 607; Vol. 73, p. 110 · Dodge et al.
  2. Indium-Catalyzed Heteroaryl–Heteroaryl Bond Formation through Nucleophilic Aromatic Substitution: Preparation of 2-Methyl-3-(thien-2-yl)-1H-indoleSubstitution Org. Synth. Vol. 91, p. 273 · Nagase and Tsuchimoto*
  3. Nucleophilic aromatic substitution of aryl fluorides by secondary nitriles: preparation of 2-(2-methoxyphenyl)-2-methylpropionitrileSubstitution Org. Synth. Vol. 79, p. 209 · Caron et al.
  4. Substitution of aryl halides with copper(I) acetylides: 2-phenylfuro[3,2-b]pyridineSubstitution Org. Synth. Coll. Vol. 6, p. 916; Vol. 52, p. 128 · Owsley and Castro
  5. Substitution reactions of 2-benzenesulfonyl cyclic ethers: tetrahydro-2-(phenylethynyl)-2H-pyranSubstitution Org. Synth. Coll. Vol. 9, p. 688; Vol. 70, p. 157 · Brown and Ley