chempirical
Reaction database

Cycloaddition reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

1–22 of 22

  1. 7α-Acetoxy-(1Hβ, 6Hβ)-bicyclo[4.4.1]undeca-2,4,8-triene via chromium-mediated higher order cycloadditionCycloaddition Org. Synth. Vol. 77, p. 121 · Rigby and Fales
  2. An improved preparation of 3-bromo-2H-pyran-2-one: an ambiphilic diene for Diels-Alder cycloadditionsCycloaddition Org. Synth. Coll. Vol. 9, p. 112; Vol. 73, p. 231 · Posner et al.
  3. Copper(I)-catalyzed photocycloaddition: 3,3-dimethyl-cis-bicyclo[3.2.0]heptan-2-oneCycloaddition Org. Synth. Coll. Vol. 7, p. 177; Vol. 62, p. 125 · Salomon and Ghosh
  4. Cu-catalyzed azide-alkyne cycloaddition: preparation of tris((1-benzyl-1H-1,2,3-triazolyl)methyl)amineCycloaddition Org. Synth. Vol. 88, p. 238 · Hein et al.
  5. [4+3] Cycloaddition in water. Synthesis of 2,4-endo,endo-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-oneCycloaddition Org. Synth. Vol. 79, p. 251 · Lautens and Bouchain
  6. [4+2] Cycloaddition of 1-dimethylamino-3-tert-butyldimethylsiloxy-1,3-butadiene with methyl acrylate: 4-hydroxymethyl-2-cyclohexen-1-oneCycloaddition Org. Synth. Vol. 78, p. 160 · Kozmin et al.
  7. [4 + 3] Cycloaddition of aminoallyl cations with 1,3-dienes: 11-oxatricyclo[4.3.1.12,5]undec-3-en-10-oneCycloaddition Org. Synth. Vol. 78, p. 212 · Oh et al.
  8. Enantioselective Rhodium-Catalyzed [2+2+2] Cycloaddition of Pentenyl Isocyanate and 4-Ethynylanisole: Preparation and Use of Taddol-pyrrolidine PhosphoramiditeCycloaddition Org. Synth. Vol. 91, p. 150 · Oberg et al.
  9. Generation and [2+2] cycloadditions of thio-substituted ketenes: trans-1-(4-methoxyphenyl)-4-phenyl-3-(phenylthio)azetidin-2-oneCycloaddition Org. Synth. Vol. 80, p. 160 · Danheiser et al.
  10. Inverse electron-demand Diels-Alder cycloaddition of a ketene dithioacetal. Copper hydride-promoted reduction of a conjugated enone. 9-Dithiolanobicyclo[3.2.2]non-6-en-2-one from troponeCycloaddition Org. Synth. Coll. Vol. 9, p. 396; Vol. 71, p. 181 · Dahnke and Paquette
  11. Nitrones for intramolecular 1,3-dipolar cycloadditions: hexahydro-1,3,3,6-tetramethyl-2,1-benzisoxazolineCycloaddition Org. Synth. Coll. Vol. 6, p. 670; Vol. 58, p. 106 · LeBel and Hwang
  12. Preparation and [2+2] cycloaddition of 1-triisopropylsiloxy-1-hexyne with methyl crotonate: 3-butyl-4-methyl-2-triisopropylsiloxy-cyclobut-2-enecarboxylic acid methyl esterCycloaddition Org. Synth. Vol. 87, p. 253 · Shubinets et al.
  13. Preparation and three-carbon + two-carbon cycloaddition of cyclopropenone 1,3-propanediol ketal: 5,5-dicyano-4-phenyl-2-cyclopenten-1-one 1,3-propanediol ketalCycloaddition Org. Synth. Coll. Vol. 8, p. 173; Vol. 65, p. 32 · Boger et al.
  14. Preparation of 1,5-Disubstituted 1,2,3-Triazoles via Ruthenium-catalyzed Azide Alkyne CycloadditionCycloaddition Org. Synth. Vol. 90, p. 96 · Oakdale and Fokin
  15. Preparation of substituted pyridines via regiocontrolled [4 + 2] cycloadditions of oximinosulfonates: methyl 5-methylpyridine-2-carboxylateCycloaddition Org. Synth. Vol. 80, p. 133 · Danheiser et al.
  16. Rhodium-catalyzed heterocycloaddition of a diazomalonate and a nitrile: 4-carbomethoxy-5-methoxy-2-phenyl-1,3-oxazoleCycloaddition Org. Synth. Coll. Vol. 9, p. 155; Vol. 74, p. 229 · Tullis and Helquist
  17. Synthesis and [3+2] cycloaddition of a 1,1-dialkoxy-2-methylenecyclopropane: 6,6-dimethyl-1-methylene-4,8-dioxaspiro[2.5]octane and cis-5-(5,5-dimethyl-1,3-dioxan-2-ylidene)hexahydro-1(2H)-pentalen-2-oneCycloaddition Org. Synth. Vol. 80, p. 144 · Nakamura et al.
  18. Synthesis of 2α-benzyloxy-8-oxabicyclo[3.2.1]oct-6-en-3-one by [4 + 3] cycloadditionCycloaddition Org. Synth. Vol. 83, p. 61 · Vidal-Pascual et al.
  19. Synthesis of a key β-lactam intermediate by a [2 + 2] cycloaddition route: 4-acetoxyazetidin-2-oneCycloaddition Org. Synth. Coll. Vol. 8, p. 3; Vol. 65, p. 135 · Mickel et al.
  20. Synthesis of substituted indazoles via [3+2] cycloaddition of benzyne and diazo compoundsCycloaddition Org. Synth. Vol. 87, p. 95 · Shi and Larock
  21. The preparation of cyclohept-4-enones by rhodium-catalyzed intermolecular [5+2] cycloadditionCycloaddition Org. Synth. Vol. 88, p. 109 · Wender et al.
  22. Trifluoromethanesulfonimide-catalyzed (2 + 2)-cycloaddition of silyl enol ethers with α,β-unsaturated esters: 1-(tert-butyldimethylsiloxy)-8-(methoxycarbonyl)-6-methylbicyclo[4.2.0]octaneCycloaddition Org. Synth. Vol. 83, p. 193 · Takasu et al.