chempirical
Reaction database

Cyclization reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

1–24 of 33

  1. [3+2]-Anionic electrocyclization using 2,3-bis(phenylsulfonyl)-1,3-butadiene: trans-4,7,7-tricarbomethoxy-2-phenylsulfonylbicyclo[3.3.0]oct-1-eneCyclization Org. Synth. Coll. Vol. 9, p. 82; Vol. 74, p. 147 · Padwa et al.
  2. [3 + 4] Annulation using a [β-(trimethylsilyl)acryloyl]silane and the lithium enolate of an α,β-unsaturated methyl ketone: (1R,6S,7S)-4-(tert-butyldimethylsiloxy)-6-(trimethylsilyl)bicyclo[5.4.0]undec-4-en-2-oneCyclization Org. Synth. Vol. 76, p. 199 · Takeda et al.
  3. (E)-1-Benzyl-3-(1-iodoethylidene)piperidine: nucleophile-promoted alkyne-iminium ion cyclizationsCyclization Org. Synth. Coll. Vol. 9, p. 46; Vol. 70, p. 111 · Arnold et al.
  4. Conjugate addition–cyclization of a cyanocuprate: 2-carbomethoxy-3-vinylcyclopentanoneCyclization Org. Synth. Coll. Vol. 8, p. 112; Vol. 66, p. 52 · Nugent and Hobbs
  5. Cyclobutanone via solvolytic cyclizationCyclization Org. Synth. Coll. Vol. 6, p. 324; Vol. 54, p. 84 · Hanack et al.
  6. Cyclopentadiene annulation via the Skattebøl rearrangement: (1R)-9,9-dimethyltricyclo-[6.1.1.02,6]deca-2,5-dieneCyclization Org. Synth. Coll. Vol. 8, p. 223; Vol. 68, p. 220 · Paquette and McLaughlin
  7. Cyclopentanone annulation via cyclopropanone derivatives: (3aβ,9bβ)-1,2,3a,4,5,9b-hexahydro-9b-hydroxy-3a-methyl-3H-benz[e]inden-3-oneCyclization Org. Synth. Coll. Vol. 9, p. 466; Vol. 74, p. 137 · Bradlee and Helquist
  8. Diazo ketone cyclization onto a benzene ring: 3,4-dihydro-1(2H)-azulenoneCyclization Org. Synth. Coll. Vol. 8, p. 196; Vol. 69, p. 180 · Scott and Sumpter
  9. Discussion Addendum for: [3 + 4] Annulation Using a [ß-(Trimethylsilyl) acryloyl]silane and the Lithium Enolate of an a,ß-Unsaturated Methyl Ketone: (1R,6S,7S)-4-(tert-Butyldimethylsiloxy)-6-(trimethylsilyl)bicyclo [5.4.0]undec-4-en-2-oneCyclization Org. Synth. Vol. 89, p. 267 · Takeda* and Sasaki
  10. Discussion Addendum for: 5-endo-trig cyclization of 1,1-difluoro-1-alkenes: synthesis of 3-butyl-2-fluoro-1-tosylindole (1H-indole, 3-butyl-2-fluoro-1-[(4-methylphenyl)sulfonyl]-)Cyclization Org. Synth. Vol. 88, p. 162 · Ichikawa.*
  11. Discussion Addendum for: synthesis of indoles by palladium catalyzed reductive N-heteroannulation of 2-nitrostyrenes: methyl indole-4-carboxylateCyclization Org. Synth. Vol. 88, p. 291 · Söderberg.*
  12. Electrophilic cyclization with N-iodosuccinimide: preparation of 5-(4-bromophenyl)-3-iodo-2-(4-methyl-phenyl)furanCyclization Org. Synth. Vol. 84, p. 199 · Sniady et al.
  13. Fragmentation-recombination Nazarov cyclization: 3,4-dimethylcyclopent-2-en-1-oneCyclization Org. Synth. Vol. 83, p. 49 · Schwartz and White
  14. Free-radical cyclization: ethyl 1-cyano-2-methylcyclohexanecarboxylateCyclization Org. Synth. Coll. Vol. 6, p. 586; Vol. 55, p. 57 · Julia and Maumy
  15. A general [3+2] annulation: cis-4-exo-isopropenyl-1,9-dimethyl-8-(trimethylsilyl)bicyclo[4.3.0]non-8-en-2-oneCyclization Org. Synth. Coll. Vol. 8, p. 347; Vol. 66, p. 8 · Danheiser et al.
  16. Generation and cyclization of 5-hexenyllithium: 2-cyclopentylacetophenoneCyclization Org. Synth. Vol. 81, p. 121 · Bailey et al.
  17. Indole synthesis by Pd-catalyzed annulation of ketones with o-iodoaniline: 1,2,3,4-tetrahydrocarbazoleCyclization Org. Synth. Vol. 78, p. 36 · Chen and Larsen
  18. Intramolecular cyclization of cis,cis-1,5-cyclooctadiene using hypervalent iodine: bicyclo[3.3.0]octane-2,6-dioneCyclization Org. Synth. Coll. Vol. 8, p. 43; Vol. 68, p. 175 · Moriarty et al.
  19. Iridium-catalyzed N-heterocyclization of primary amines with diols: N-benzylpiperidineCyclization Org. Synth. Vol. 83, p. 217 · Fujitaa et al.
  20. Macrolides from cyclization of ω-bromocarboxylic acids: 11-hydroxyundecanoic lactoneCyclization Org. Synth. Coll. Vol. 6, p. 698; Vol. 58, p. 98 · Galli and Mandolini
  21. Phosphine-catalyzed [3 + 2] annulation: synthesis of ethyl 5-(tert-butyl)-2-phenyl-1-tosyl-3-pyrroline-3-carboxylateCyclization Org. Synth. Vol. 88, p. 138 · Andrews and Kwon
  22. Phosphine-catalyzed [4+2] annulation: synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylateCyclization Org. Synth. Vol. 86, p. 212 · Lu and Kwon
  23. Photocyclization of an enone to an alkene: 6-methylbicyclo[4.2.0]octan-2-oneCyclization Org. Synth. Coll. Vol. 7, p. 315; Vol. 62, p. 118 · Cargill et al.
  24. Preparation of 3-Alkylated Oxindoles from N-Benzyl Aniline via a Cu(II)-Mediated Anilide Cyclization ProcessCyclization Org. Synth. Vol. 89, p. 438 · Pugh and Taylor