chempirical
Reaction database

Cyclization reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

25–44 of 44

  1. Free-radical cyclization: ethyl 1-cyano-2-methylcyclohexanecarboxylateCyclization Org. Synth. Coll. Vol. 6, p. 586; Vol. 55, p. 57 · Julia and Maumy
  2. A general [3+2] annulation: cis-4-exo-isopropenyl-1,9-dimethyl-8-(trimethylsilyl)bicyclo[4.3.0]non-8-en-2-oneCyclization Org. Synth. Coll. Vol. 8, p. 347; Vol. 66, p. 8 · Danheiser et al.
  3. Generation and cyclization of 5-hexenyllithium: 2-cyclopentylacetophenoneCyclization Org. Synth. Vol. 81, p. 121 · Bailey et al.
  4. Indole synthesis by Pd-catalyzed annulation of ketones with o-iodoaniline: 1,2,3,4-tetrahydrocarbazoleCyclization Org. Synth. Vol. 78, p. 36 · Chen and Larsen
  5. Intramolecular cyclization of cis,cis-1,5-cyclooctadiene using hypervalent iodine: bicyclo[3.3.0]octane-2,6-dioneCyclization Org. Synth. Coll. Vol. 8, p. 43; Vol. 68, p. 175 · Moriarty et al.
  6. Iridium-catalyzed N-heterocyclization of primary amines with diols: N-benzylpiperidineCyclization Org. Synth. Vol. 83, p. 217 · Fujitaa et al.
  7. Macrolides from cyclization of ω-bromocarboxylic acids: 11-hydroxyundecanoic lactoneCyclization Org. Synth. Coll. Vol. 6, p. 698; Vol. 58, p. 98 · Galli and Mandolini
  8. Phosphine-catalyzed [3 + 2] annulation: synthesis of ethyl 5-(tert-butyl)-2-phenyl-1-tosyl-3-pyrroline-3-carboxylateCyclization Org. Synth. Vol. 88, p. 138 · Andrews and Kwon
  9. Phosphine-catalyzed [4+2] annulation: synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylateCyclization Org. Synth. Vol. 86, p. 212 · Lu and Kwon
  10. Photocyclization of an enone to an alkene: 6-methylbicyclo[4.2.0]octan-2-oneCyclization Org. Synth. Coll. Vol. 7, p. 315; Vol. 62, p. 118 · Cargill et al.
  11. Preparation of 3-Alkylated Oxindoles from N-Benzyl Aniline via a Cu(II)-Mediated Anilide Cyclization ProcessCyclization Org. Synth. Vol. 89, p. 438 · Pugh and Taylor
  12. Preparation of 5-Hydroxycyclopentenones Via Conjugate Addition-Initiated Nazarov CyclizationCyclization Org. Synth. Vol. 91, p. 93 · Brooks et al.
  13. Preparation of Tetrahydroisoquinoline-3-ones Via Cyclization of Phenyl Acetamides Using Eaton's ReagentCyclization Org. Synth. Vol. 89, p. 44 · Yang et al.
  14. Reductive annulation of vinyl sulfones: bicyclo[4.3.0.]non-1-en-4-oneCyclization Org. Synth. Coll. Vol. 8, p. 38; Vol. 67, p. 163 · Lin and Paquette
  15. Synthesis of 2,3-disubstituted indoles via palladium-catalyzed annulation of internal alk ynes: 3-methyl-2-(trimethylsilyl)indoleCyclization Org. Synth. Vol. 88, p. 377 · Chen et al.
  16. Synthesis of Et2SBr•SbCl5Br and its use in biomimetic brominative polyene cyclizationsCyclization Org. Synth. Vol. 88, p. 54 · Snyder and Treitler
  17. Synthesis of indoles by palladium-catalyzed reductive N-heteroannulation of 2-nitrostyrenes: methyl indole-4-carboxylateCyclization Org. Synth. Vol. 80, p. 75 · Söderberg et al.
  18. Synthesis of Quinolines by Electrophilic Cyclization of N-(2-Alkynyl)Anilines: 3-Iodo-4-PhenylquinolineCyclization Org. Synth. Vol. 89, p. 294 · Chen et al.
  19. 5-endo-trig cyclization of 1,1-difluoro-1-alkenes: synthesis of 3-butyl-2-fluoro-1-tosylindoleCyclization Org. Synth. Vol. 83, p. 111 · Ichikawa et al.
  20. Vinyl radical cyclization via addition of tin radicals to triple bonds: 3-methylene-4-isopropyl-1,1-cyclopentanedicarboxylic acid, dimethyl esterCyclization Org. Synth. Coll. Vol. 8, p. 381; Vol. 66, p. 75 · Mook and Sher