Tris(hydroxymethyl)aminomethane hydrochloride

C4H12ClNO3CAS 1185-53-1157.59 g/mol

Open in Covalent MOL file
HClNH2OHHOOH
AlcoholPrimary amine

Properties

Molecular formula
C4H12ClNO3
Molar mass
157.59 g/mol
Exact mass
157.0506 Da
Melting point
150–150.8 °C
logP
-1.92Crippen estimate
Polar surface area
86.7 Ų
H-bond donors / acceptors
4 / 4
Rotatable bonds
3

Hazards

Warning
Irritant (GHS07)

Aggregated from 180 ECHA notifications, via PubChem; a share says how many notifiers assign that statement.

Precautionary statements

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, P501

Identifiers

CAS number
1185-53-1
SMILES
Cl.NC(CO)(CO)CO
InChIKey
QKNYBSVHEMOAJP-UHFFFAOYSA-N
InChI
InChI=1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H

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Names and synonyms

11 names
  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1)
  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride
  • Tris chloride
  • Tris hydrochloride
  • Tromethamine hydrochloride
  • Trizma hydrochloride
  • 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride
  • Tri(hydroxymethyl)aminomethane hydrochloride
  • T 6666
  • Tris-hydrochloric acid
  • Tris-HCl

Work with Tris(hydroxymethyl)aminomethane hydrochloride

Predict the NMR spectrum1H and 13C shifts with multiplicities Make a solutionWhat to weigh for any molarity and volume Check drug-likenessLipinski, Veber and lead-likeness Isotope patternExact mass and the mass spectrum pattern

Stereoisomers, salts and isotopologues

The same compound in another form: other stereochemistry, a salt or hydrate, the free acid or base, or an isotope-labelled version.

Tris77-86-1Free base Dinoprost tromethamine38562-01-5Salt Ketorolac tromethamine74103-07-4Salt Fosfomycin tromethamine78964-85-9Salt S-(+)-Ketoprofen trometamol156604-79-4Salt Carboprost tromethamine58551-69-2Salt Lodoxamide tromethamine63610-09-3Salt Tris-acetate6850-28-8Salt Phosphoric acid, mono(4-nitrophenyl) ester, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:2)68189-42-4Salt

Similar compounds

[1-Aminocyclopentyl]methanol10316-79-755 % similar 2-Amino-2-ethyl-1,3-propanediol115-70-852 % similar Bicyclo[1.1.1]pentan-3-amine,hydrochloride22287-35-043 % similar Fingolimod hydrochloride162359-56-040 % similar Amantadine hydrochloride665-66-739 % similar 2-Amino-2-methyl-1,3-propanediol115-69-536 % similar Aminomethyl propanol124-68-536 % similar Memantine hydrochloride41100-52-134 % similar

Tanimoto similarity of circular fingerprints over the whole catalogue.

All similar compounds

Elsewhere

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