Suzuki reaction
Named reactionCross-coupling
The Suzuki reaction or Suzuki coupling is an organic reaction that uses a palladium complex catalyst to cross-couple a boronic acid to an organohalide. It was first published in 1979 by Akira Suzuki, and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their contribution to the discovery and development of noble metal catalysis in organic synthesis. This reaction is sometimes telescoped with the related Miyaura borylation; the combination is the Suzuki–Miyaura reaction. It is widely used to synthesize polyolefins, styrenes, and substituted biphenyls.
Checked procedures in Organic Syntheses
- Accelerated Suzuki coupling via a ligandless palladium catalyst: 4-methoxy-2'-methylbiphenyl
- Discussion Addendum for: Suzuki-Miyaura Cross-Coupling: Preparation of 2'-Vinylacetanilide
- 2-(4-Methoxyphenyl)-2-cyclohexen-1-one: preparation of 2-iodo-2-cyclohexen-1-one and Suzuki coupling with 4-methoxyphenylboronic acid (2-Cyclohexen-1-one, 2-(4-methoxyphenyl)- and 2-Cyclohexen-1-one, 2-iodo-))
- Palladium-catalyzed alkyl-alkyl Suzuki cross-couplings of primary alkyl bromides at room temperature: (13-chlorotridecyloxy)triethylsilane
- Preparation of 1-Monoacylglycerols via the Suzuki-Miyaura Reaction: 2,3-Dihydroxypropyl (Z)-tetradec-7-enoate
- Suzuki-Miyaura cross-coupling: preparation of 2'-vinylacetanilide
- Synthesis of 3-pyridylboronic acid and its pinacol ester. Application of 3-pyridylboronic acid in Suzuki coupling to prepare 3-pyridin-3-ylquinoline
- Synthesis of unsymmetrical biaryls using a modified Suzuki cross-coupling: 4-biphenylcarboxaldehyde