Diastereoselective α-alkylation of β-hydroxycarboxylic esters through alkoxide enolates: diethyl (2S, 3R)-(+)-3-allyl-2-hydroxysuccinate from diethyl (S)-(−)-malate
CAS index name: Butanedioic acid, 2-hydroxy-3-(2-propenyl)-, diethyl ester, [S-(R,S)]
Organic Syntheses
A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.
Reagents
| Compound | Role | Equiv | MW (g/mol) | ρ (g/mL) | Safety |
|---|---|---|---|---|---|
| Butane106-97-8 · C4H10 | product | — | 58.12 | — | Danger |