Mukaiyama aldol addition

In organic chemistry, the Mukaiyama aldol addition is an organic reaction and a type of aldol reaction between a silyl enol ether (R2C=CR−O−Si(CH3)3) and an aldehyde (R−CH=O) or formate (R−O−CH=O). The reaction was reported in 1973 by Teruaki Mukaiyama, Koichi Narasaka and Kazuo Banno from the Laboratory of Organic Chemistry, Tokyo Institute of Technology. His choice of reactants allows for a crossed aldol reaction between an aldehyde and a ketone (>C=O), or a different aldehyde without self-condensation of the aldehyde. For this reason the reaction is used extensively in organic synthesis.