Lossen rearrangement

Overview

The Lossen rearrangement is the conversion of an acyl hydroxamate to an isocyanate and carboxylic acid side product. The isocyanate can be used further to generate ureas in the presence of amines or generate amines in the presence of H2O.

Actions

• This entry doesn't have stoichiometric equivalents on file yet — the Reaction Scale Calculator needs at least one participant tagged with an equivalents value.
• Mechanism / source ↗