Leimgruber–Batcho indole synthesis

Overview

The Leimgruber–Batcho indole synthesis is a series of organic reactions that produce indoles from o-nitrotoluenes 1.[1][2][3] The first step is the formation of an enamine 2 using N,N-dimethylformamide, dimethyl acetal and pyrrolidine.[4] The desired indole 3 is then formed in a second step by reductive cyclisation.

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