Kröhnke pyridine synthesis

Overview

Kröhnke pyridine synthesis is a reaction in organic synthesis that occurs between α-pyridinium methyl ketone salts and α, β-unsaturated carbonyl compounds and is used to generate highly functionalized pyridines. Pyridines occur widely in natural and synthetic products, so there is wide interest in routes for their synthesis. The method is named after Fritz Kröhnke.

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