Grignard reaction
Named reactionOrganometallic addition
The Grignard reaction (French: [ɡʁiɲaʁ]) is an organometallic chemical reaction in which, according to the classical definition, carbon alkyl, allyl, vinyl, or aryl magnesium halides (Grignard reagent) are added to the carbonyl groups of either an aldehyde or ketone under anhydrous conditions. This reaction is important for the formation of carbon–carbon bonds.
Checked procedures in Organic Syntheses
- Aldehydes from 4,4-dimethyl-2-oxazoline and Grignard reagents: o-anisaldehyde
- Cross-Coupling of Alkenyl/Aryl Carboxylates with Grignard Reagents via Fe-Catalyzed C-O Bond Activation
- Formyl transfer to Grignard reagents with N-formylpiperidine: 3-phenylpropionaldehyde
- Highly reactive magnesium for the preparation of Grignard reagents: 1-norbornanecarboxylic acid
- Iron-Catalyzed Selective Conjugate Addition of Aryl Grignard Reagents to 2,4-Alkadienoates: tert-Butyl (Z)-5-Phenyl-3-hexenoate
- Ketones from carboxylic acids and Grignard reagents: methyl 6-oxodecanoate
- Nickel-catalyzed coupling of aryl O-carbamates with Grignard reagents: 2,7-dimethylnaphthalene
- Nucleophilic hydroxymethylation by the (isopropoxydimethylsilyl)methyl Grignard reagent: 1-(hydroxymethyl)cyclohexanol from cyclohexanone