Debus–Radziszewski imidazole synthesis

Overview

The Debus–Radziszewski imidazole synthesis is a multi-component reaction used for the synthesis of imidazoles from a 1,2-dicarbonyl, an aldehyde, and ammonia or a primary amine. The method is used commercially to produce several imidazoles. The process is an example of a multicomponent reaction.

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