Bradsher cycloaddition

Overview

The Bradsher cycloaddition reaction, also known as the Bradsher cyclization reaction is a form of the Diels–Alder reaction which involves the [4+2] addition of a common dienophile with a cationic aromatic azadiene such as acridizinium or isoquinolinium.

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• [4+2] CYCLOADDITION OF 1-DIMETHYLAMINO-3-tert-BUTYLDIMETHYLSILOXY-1,3-BUTADIENE WITH METHYL ACRYLATE: 4-HYDROXYMETHYL-2-CYCLOHEXEN-1-ONE (2-Cyclohexen-1-one, 4-(hydroxymethyl)-) Cycloaddition
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• Azide-alkyne Huisgen cycloaddition Cycloaddition