Reaction database

Electrophilic aromatic substitution reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

1–2 of 2

  1. Friedel-Crafts acylation: benzene + acetyl chloride → acetophenoneElectrophilic aromatic substitution Textbook electrophilic aromatic substitution via the AlCl3-generated acylium ion. Worked example · after Friedel-Crafts 1877 Scale
  2. Catalytic Intramolecular Friedel-Crafts Reaction of Benzyl Meldrum's Acid Derivatives: Preparation of 5,6-Dimethoxy-2-Methyl-1-IndanoneElectrophilic aromatic substitution Org. Synth. Vol. 89, p. 115 · Lou et al.