Reaction database

Substitution reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

1–2 of 2

  1. Mitsunobu reaction: benzyl alcohol + phthalimide → N-benzyl phthalimideSubstitutiondehydration PPh3/DIAD-mediated dehydrative coupling of an alcohol with an acidic pronucleophile (pKa ≲ 13). Worked example · after Mitsunobu 1967 Scale
  2. Williamson ether synthesis: sodium ethoxide + 1-bromobutane → ethyl butyl etherSubstitutionSN2 Textbook SN2 ether-formation. Worked example · after Williamson 1850 Scale