Reaction database

Electrophilic aromatic substitution reactions

3,374 reactions: 10 worked examples with a reagent table you can scale, 503 named reactions and 2,861 checked procedures from Organic Syntheses.

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  1. Friedel-Crafts acylation: benzene + acetyl chloride → acetophenoneElectrophilic aromatic substitution Textbook electrophilic aromatic substitution via the AlCl3-generated acylium ion. Worked example · after Friedel-Crafts 1877 Scale