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Glibenclamide
CAS: 10238-21-8 | C23H28ClN3O5S
2D Structure
3D Structure
Loading 3D structure...
Basic Information
CAS Registry Number:
10238-21-8
Molecular Formula:
C23H28ClN3O5S
Molecular Mass:
494.01 g/mol
Names and Synonyms:
Glibenclamide
Tiabet
Orabetic
Glitisol
Prodiabet
Glukovital
Glynase
Melix
Glucal
Diaben
Norboral
Semi-Daonil
Wuglucon
Gl
Dia-basan
Glucoremed
Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
Urea, 1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexyl-
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide
1-[4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl]-3-cyclohexylurea
Glibenclamide
Glybenzcyclamide
Glyburide
HB 419
N-[4-(β-(2-Methoxy-5-chlorobenzamido)ethyl)benzosulfonyl]-N′-cyclohexylurea
1-[[-p-[2-(5-Chloro-o-anisamido)ethyl]phenyl]sulfonyl]-3-cyclohexylurea
U 26452
N-4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl-N′-cyclohexylurea
HD 419
N-[4-[β-(2-Methoxy-5-chlorobenzamido)ethyl]benzenesulfonyl]-N′-cyclohexylurea
Maninil
Euglucon 5
UR 606
1-[p-2-(5-Chloro-o-anisamido)ethylphenylsulfonyl]-3-cyclohexylurea
Daonil
Euglucon
Gilemal
Diabeta
Euglucan
Euglykon
Semi-Euglucon N
Semi-Euglucon
Daonil N
Glycolande N
Betanase
Betanaz
Micronase
Med-Glionil
Humedia
Miglucan
Betanese 5
Glibens
Glucohexal
Debtan
Antibet
Dibelet
Glimel
Cytagon
Glibet
Azuglucon
Glycomin
Glibetic
Glucolon
Glisulin
Glicem
Glyben
GBN 5
Bastiverit
Glibesyn
Sugril
Suraben
Gliben
Glucoven
Libanil
Glucomid
Gliban
Glibenil
Hemi-Daonil
Calabren
Benclamin
Glamide
Glibil
Pira
Gliboral
Glucobene
Renabetic
Apo-Glibenclamide
Glimide
Glidiabet
Gluben
Yuglucon
Glycolande
Duraglucon
Gliben-Puren N
Gluco-Tabinen
Abbenclamide
Adiab
Diabiphage
Glubate
Glimidstada
Glibomet
RP 1127
Glustat
Glyform
Gluvans
Glicuformine
Glymet
Glyburine
5-Chloro-N-(2-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenyl)ethyl)-2-methoxybenzamide
Diazet
Amglidia
Identifiers:
SMILES:
COc1ccc(Cl)cc1C(O)=NCCc1ccc(S(=O)(=O)NC(O)=NC2CCCCC2)cc1
InChI:
InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)
Key Properties
Melting Point
169 °C
CAS Common Chemistry
Spectral Data
NMR, IR, and Mass spectral data
1H NMR
13C NMR
Predicting NMR spectra...
10 ppm
9
8
7
6
5
4
3
2
1
0 ppm
| Shift (ppm) | Multiplicity | Integration | Assignment |
|---|
200 ppm
180
160
140
120
100
80
60
40
20
0 ppm
| Shift (ppm) | DEPT | Assignment |
|---|
Note: These NMR spectra are predicted computationally and may differ from experimental data. Predictions are based on chemical environment analysis.
All Properties
Comprehensive physical and chemical properties
| Property | Value | Source |
|---|---|---|
| Molecular Mass | 494.01 g/mol | CAS Common Chemistry |
| 494.0130000000003 g/mol | RDKit | |
| 493.14381967599996 g/mol | RDKit | |
| Canonical SMILES | O=C(NC1CCCCC1)NS(=O)(=O)C2=CC=C(C=C2)CCNC(=O)C3=CC(Cl)=CC=C3OC | CAS Common Chemistry |
| InChI | InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) | CAS Common Chemistry |
| InChI Key | InChIKey=ZNNLBTZKUZBEKO-UHFFFAOYSA-N | CAS Common Chemistry |
| Melting Point | 169 °C | CAS Common Chemistry |
| Name | Glibenclamide | CAS Common Chemistry |
| Heavy Atom Count | 33 | RDKit |
| Hydrogen Bond Acceptors | 5 | RDKit |
| Hydrogen Bond Donors | 3 | RDKit |
| Rotatable Bonds | 8 | RDKit |
| Aromatic Ring Count | 2 | RDKit |
| Topological Polar Surface Area | 120.58000000000001 Ų | RDKit |
| LogP | 4.420900000000003 | RDKit |
| Molar Refractivity | 129.44110000000003 | RDKit |
