Mono-C-methylation of arylacetonitriles and methyl arylacetates by dimethyl carbonate: a general method for the synthesis of pure 2-arylpropionic acids. 2-Phenylpropionic acid

CAS index name: Benzeneacetic acid, α-methyl-

Organic Syntheses

Reaction scheme of Mono-C-methylation of arylacetonitriles and methyl arylacetates by dimethyl carbonate: a general method for the synthesis of pure 2-arylpropionic acids. 2-Phenylpropionic acid from Organic Syntheses
Scheme as published in Org. Synth. Vol. 76, p. 169.

A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.

Reagents

CompoundRoleEquivMW (g/mol)ρ (g/mL)Safety
2-Phenylpropionic acid492-37-5 · C9H10O2 product — 150.18 — Irritant (GHS07)Warning

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