Lipase-catalyzed kinetic resolution of alcohols via chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol

CAS index name: Cyclohexanol, 2-phenyl-, (1R-trans)- and cyclohexanol, 2-phenyl-, (1S-trans)-

Organic Syntheses

Reaction scheme of Lipase-catalyzed kinetic resolution of alcohols via chloroacetate esters: (−)-(1R,2S)-trans-2-phenylcyclohexanol and (+)-(1S,2R)-trans-2-phenylcyclohexanol from Organic Syntheses
Scheme as published in Org. Synth. Coll. Vol. 8, p. 516; Vol. 69, p. 1.

A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.

Reagents

CompoundRoleEquivMW (g/mol)ρ (g/mL)Safety
(+)-trans-2-Phenylcyclohexanol34281-92-0 · C12H16O product — 176.26 — —

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