(S)-(−)-1-Amino-2-methoxymethylpyrrolidine (SAMP) and (R)-(+)-1-amino-2-methoxymethylpyrrolidine (RAMP), versatile chiral auxiliaries

CAS index name: 1-Pyrrolidinamine, 2-(methoxymethyl)-, (S) 1-Pyrrolidinamine, 2-(methoxymethyl)-, (R)

Organic Syntheses

Procedure on orgsyn.org
Reaction scheme of (S)-(−)-1-Amino-2-methoxymethylpyrrolidine (SAMP) and (R)-(+)-1-amino-2-methoxymethylpyrrolidine (RAMP), versatile chiral auxiliaries from Organic Syntheses
Scheme as published in Org. Synth. Coll. Vol. 8, p. 26; Vol. 65, p. 173.

A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.

Reagents

CompoundRoleEquivMW (g/mol)ρ (g/mL)Safety
Ethylene glycol107-21-1 · C2H6O2 product — 62.07 1.110 Irritant (GHS07)WarningSDS

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Google Scholar PubMed Wikipedia DOI 10.15227/orgsyn.065.0173