Trifluoroacetylation of amines and amino acids under neutral, mild conditions: N-trifluoroacetanilide and N-trifluoroacetyl-L-tyrosine

CAS index name: Acetamide, 2,2,2-trifluoro-N-phenyl- and L-Tyrosine, N-(trifluoroacetyl)-

Organic Syntheses

Procedure on orgsyn.org
Reaction scheme of Trifluoroacetylation of amines and amino acids under neutral, mild conditions: N-trifluoroacetanilide and N-trifluoroacetyl-L-tyrosine from Organic Syntheses
Scheme as published in Org. Synth. Coll. Vol. 6, p. 1004; Vol. 56, p. 122.

A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.

Reagents

CompoundRoleEquivMW (g/mol)ρ (g/mL)Safety
2,2,2-Trifluoro-N-phenylacetamide404-24-0 · C8H6F3NO product — 189.14 — Irritant (GHS07)Warning

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Google Scholar PubMed Wikipedia DOI 10.15227/orgsyn.056.0122