Phase-transfer Hofmann carbylamine reaction: tert-butyl isocyanide
CAS index name: Propane, 2-isocyano-2-methyl-
Organic SynthesesRearrangement
A checked procedure from Organic Syntheses, the journal whose preparations are repeated in a second laboratory before publication. The full experimental, with amounts, hazards and characterisation data, is on orgsyn.org.
Reagents
| Compound | Role | Equiv | MW (g/mol) | ρ (g/mL) | Safety |
|---|---|---|---|---|---|
| tert-Butyl isocyanide7188-38-7 · C5H9N | product | — | 83.13 | — | Danger |
More rearrangement reactions
- 1-N-Acylamino-1,3-dienes from 2,4-pentadienoic acids by the Curtius rearrangement: benzyl trans-1,3-butadiene-1-carbamate
- Alkenes via Hofmann elimination: use of ion-exchange resin for preparation of quaternary ammonium hydroxides: diphenylmethyl vinyl ether
- Allyl Cyanate-To-Isocyanate Rearrangement: Preparation of tert-Butyl 3,7-dimethylocta-1,6-dien-3-ylcarbamate
- Asymmetric rearrangement of allylic trichloroacetimidates: preparation of (S)-2,2,2-trichloro-N-(1-propylallyl)acetamide
- Base-induced rearrangement of epoxides to allylic alcohols: trans-pinocarveol (Bicyclo[3.3.1]heptan-3-ol, 6,6-dimethyl-2-methylene-, (1α,3α,5α-)
- Benzalpinacolone