Leimgruber–Batcho indole synthesis
Named reaction
The Leimgruber–Batcho indole synthesis is a series of organic reactions that produce indoles from o-nitrotoluenes 1. The first step is the formation of an enamine 2 using N,N-dimethylformamide, dimethyl acetal and pyrrolidine. The desired indole 3 is then formed in a second step by reductive cyclisation.