Azide-alkyne Huisgen cycloaddition
Named reactionCycloaddition
The azide-alkyne Huisgen cycloaddition is a 1,3-dipolar cycloaddition between an azide and a terminal or internal alkyne to give a 1,2,3-triazole. Rolf Huisgen was the first to understand the scope of this organic reaction. American chemist Karl Barry Sharpless has referred to copper-catalyzed version of this cycloaddition as "the cream of the crop" of click chemistry and "the premier example of a click reaction".
More cycloaddition reactions
- Bradsher cycloaddition
- Intramolecular Diels–Alder cycloaddition
- Diels–Alder cycloaddition: cyclopentadiene + maleic anhydride → endo-norbornene-2,3-dicarboxylic anhydride
- 7α-Acetoxy-(1Hβ, 6Hβ)-bicyclo[4.4.1]undeca-2,4,8-triene via chromium-mediated higher order cycloaddition
- An improved preparation of 3-bromo-2H-pyran-2-one: an ambiphilic diene for Diels-Alder cycloadditions
- Copper(I)-catalyzed photocycloaddition: 3,3-dimethyl-cis-bicyclo[3.2.0]heptan-2-one