Tool · Distillation

Pressure–Temperature Nomograph

Solve any two of compound + pressure, compound + observed boiling point, atmospheric bp + pressure, or atmospheric bp + observed bp. When the compound has Antoine constants in our database, the answer is computed exactly from log₁₀(P) = A − B/(T+C); otherwise we fall back to the compound-agnostic Clausius-Clapeyron approximation (the same one Sigma-Aldrich's tool uses).

Try a common scenario

Water at 1 atm Ethanol at house vacuum (12 mmHg) DMF at 5 mmHg DMSO at 10 mmHg Toluene at 50 mmHg

Antoine: NIST WebBook constants in the antoine_parameters table. Sigma fallback: Clausius-Clapeyron at constant ΔH_vap, valid to ~±5 °C for non-polar compounds and less reliable for polar/H-bonding species — the very reason replacing Sigma's compound-agnostic nomograph with our compound-specific one is meaningful.

Related chemistry tools

Fractional Distillation Predictor Predict the cuts you'll collect from a multi-component mixture, with azeotrope warnings. Vapor Pressure Calculator Estimate vapor pressure at any temperature from Antoine constants. Pressure Unit Converter Convert between mmHg, torr, mbar, atm, psi, and kPa. Molar Mass Calculator Molecular weight and percent composition from any chemical formula.