chempirical

N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-A]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine

C26H24N8O2CAS 937263-43-9480.53 g/mol

Open in Covalent MOL file
HNNNNHNOONNN
EtherSecondary amine

Properties

Molecular formula
C26H24N8O2
Molar mass
480.53 g/mol
Exact mass
480.2022 Da
logP
4.90Crippen estimate
Polar surface area
110.8 Ų
H-bond donors / acceptors
2 / 8
Rotatable bonds
5

Identifiers

CAS number
937263-43-9
SMILES
Cc1cc(Nc2ncnc3ccc(N=C4NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1
InChIKey
SDEAXTCZPQIFQM-UHFFFAOYSA-N
InChI
InChI=1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)

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Names and synonyms

5 names
  • 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-
  • ARRY 380
  • ONT 380
  • Tucatinib
  • Tukysa

Work with N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-A]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine

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Similar compounds

N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide194423-06-832 % similar

Tanimoto similarity of circular fingerprints over the whole catalogue. All similar compounds

Elsewhere

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