Tolbutamide

C12H18N2O3SCAS 64-77-7270.35 g/mol

Open in Covalent MOL file
HNOHNSOO
Sulfonamide

Properties

Molecular formula
C12H18N2O3S
Molar mass
270.35 g/mol
Exact mass
270.1038 Da
Density
1.245 g/mL (at 25 °C)
Melting point
128.5–129.5 °C
pKa
5.16
Water solubility
109 mg/L
logP
1.99Crippen estimate
Polar surface area
78.8 Ų
H-bond donors / acceptors
2 / 3
Rotatable bonds
5

Hazards

Danger
Irritant (GHS07)Health Hazard (GHS08)

Aggregated from 7 ECHA notifications, via PubChem; a share says how many notifiers assign that statement.

Precautionary statements

P203, P260, P261, P264, P270, P272, P280, P301+P317, P302+P352, P308+P316, P318, P321, P330, P333+P317, P362+P364, P405, P501

Identifiers

CAS number
64-77-7
SMILES
CCCCN=C(O)NS(=O)(=O)c1ccc(C)cc1
InChIKey
JLRGJRBPOGGCBT-UHFFFAOYSA-N
InChI
InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

Weigh it out

Type any one amount. The others follow from the molar mass and density.

Names and synonyms

52 names · show all
  • Benzenesulfonamide, N-[(butylamino)carbonyl]-4-methyl-
  • Urea, 1-butyl-3-(p-tolylsulfonyl)-
  • N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
  • D 860
  • Artosin
  • Butamide
  • 1-Butyl-3-(p-methylphenylsulfonyl)urea
  • N-Butyl-N′-p-toluenesulfonylurea
  • 1-Butyl-3-(p-tolylsulfonyl)urea
  • N-n-Butyl-N′-tosylurea
  • Diaben
  • Diabuton
  • Dolipol
  • Ipoglicone
  • Mobenol
  • Orabet
  • Oralin
  • Orinase
  • Rastinon
  • N-(Sulfonyl-p-methylbenzene)-N′-n-butylurea
  • Toluina
  • N-(p-Tolylsulfonyl)-N′-butylcarbamide
  • 3-(p-Tolyl-4-sulfonyl)-1-butylurea
  • Diabetol
  • Butamid
  • N-(4-Methylphenylsulfonyl)-N′-butylurea
  • N-(4-Methylbenzenesulfonyl)-N′-butylurea
  • Tolbutamid
  • N-Butyl-N′-(p-tolylsulfonyl)urea
  • N-Butyl-N′-(4-methylphenylsulfonyl)urea
  • Aglicid
  • Arkozal
  • Artozin
  • Diabetamid
  • Orezan
  • Orinaz
  • Tolumid
  • Toluvan
  • Oterben
  • Tolbusal
  • Willbutamide
  • HLS 831
  • N-(p-Methylbenzenesulfonyl)-N′-butylurea
  • Tolumide
  • Pramidex
  • Diasulfon
  • Glyconon
  • U 2043
  • NSC 23813
  • NSC 87833
  • 1-Butyl-3-(4-methylphenyl)sulfonylurea
  • 3-Butyl-1-(4-methylbenzenesulfonyl)urea

Work with Tolbutamide

Predict the NMR spectrum1H and 13C shifts with multiplicities Make a solutionWhat to weigh for any molarity and volume Check drug-likenessLipinski, Veber and lead-likeness Isotope patternExact mass and the mass spectrum pattern

Similar compounds

Chlorpropamid94-20-264 % similar Tolazamide1156-19-059 % similar Gliclazide21187-98-455 % similar N-Butyl-4-methylbenzenesulfonamide1907-65-953 % similar Tosylurea1694-06-050 % similar Grapiprant415903-37-647 % similar 4-Methyl-N-[[[3-[[(4-methylphenyl)sulfonyl]oxy]phenyl]amino]carbonyl]benzenesulfonamide232938-43-147 % similar Tos-arg-oh1159-15-546 % similar

Tanimoto similarity of circular fingerprints over the whole catalogue.

All similar compounds

Same formula

1-[3-Amino-4-(methylsulfonyl)phenyl]-4-piperidinol1219957-10-4 1-[3-Amino-4-(ethylsulfonyl)phenyl]-3-pyrrolidinol1220021-65-7 2-(Ethylsulfonyl)-5-(4-morpholinyl)benzenamine1220034-99-0

Elsewhere

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