Methylone
Properties
- Molecular formula
- C11H13NO3
- Molar mass
- 207.23 g/mol
- Exact mass
- 207.0895 Da
- logP
- 1.21Crippen estimate
- Polar surface area
- 47.6 Ų
- H-bond donors / acceptors
- 1 / 4
- Rotatable bonds
- 3
Methylone (TSND-201) - β-keto analog of MDMA differing only by a single ketone insertion that eliminates 5-HT2A activity (so non-hallucinogenic) while preserving rapid-onset monoamine release. Transcend Therapeutics' Phase-2 IMPACT-1 trial in 65 severe-PTSD participants hit its primary endpoint with a placebo-adjusted CAPS-5 reduction of -9.64 at Day 64. The FDA granted Breakthrough Therapy designation in July 2025; on 27 April 2026 - nine days after Trump's psychedelic executive order - the agency awarded Transcend a National Priority Voucher, putting methylone on a 1-2 month review-clock pathway and ahead of MDMA itself in the regulatory queue. Otsuka Pharmaceutical announced its acquisition of Transcend the same year.
Hazards
No GHS classification is on file for this compound. That is not evidence that it is harmless. Search the SDS library
Identifiers
186028-79-5CNC(C)C(=O)c1ccc2c(c1)OCO2VKEQBMCRQDSRET-UHFFFAOYSA-NInChI=1S/C11H13NO3/c1-7(12-2)11(13)8-3-4-9-10(5-8)15-6-14-9/h3-5,7,12H,6H2,1-2H3Weigh it out
Type any one amount. The others follow from the molar mass.
Names and synonyms
6 names
- 1-Propanone, 1-(1,3-benzodioxol-5-yl)-2-(methylamino)-
- 1-(1,3-Benzodioxol-5-yl)-2-(methylamino)-1-propanone
- 2-Methylamino-1-(3,4-methylenedioxyphenyl)propan-1-one
- 3,4-Methylenedioxy-N-methylcathinone
- MDMC
- 1-(2H-1,3-Benzodioxol-5-yl)-2-(methylamino)propan-1-one
Work with Methylone
Similar compounds
Tanimoto similarity of circular fingerprints over the whole catalogue. All similar compounds