Losartan

C₂₂H₂₃ClN₆OCAS 114798-26-4422.92 g/mol

Open in Covalent MOL file

Alcohol Aryl halide

Properties

Molecular formula: C₂₂H₂₃ClN₆O
Molar mass: 422.92 g/mol
Exact mass: 422.1622 Da
Melting point: 184 °C
pKa: 5
logP: 4.27Crippen estimate
Polar surface area: 92.5 Å²
H-bond donors / acceptors: 2 / 5
Rotatable bonds: 8

Hazards

Danger

H315 Causes skin irritation48.1% of notifiers
H317 May cause an allergic skin reaction48.1% of notifiers
H319 Causes serious eye irritation49.4% of notifiers
H335 May cause respiratory irritation48.1% of notifiers
H360 May damage fertility or the unborn child46.9% of notifiers
H362 May cause harm to breast-fed children46.9% of notifiers
H413 May cause long lasting harmful effects to aquatic life46.9% of notifiers

Aggregated from 81 ECHA notifications, via PubChem; a share says how many notifiers assign that statement.

Precautionary statements

P203, P260, P261, P263, P264, P264+P265, P270, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, P501

Identifiers

CAS number

114798-26-4

SMILES

CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1

InChIKey

PSIFNNKUMBGKDQ-UHFFFAOYSA-N

InChI

InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)

Weigh it out

Type any one amount. The others follow from the molar mass.

Names and synonyms

14 names · show all

Lozap
Xartan
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol
DUP 89
Lortaan
2-Butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-1H-imidazole-5-methanol
Angizaar
Allisartan
1-[1-[[2′-(2H-Tetrazol-5-yl)biphenyl-4-yl]methyl]-2-butyl-4-chloro-1H-imidazol-5-yl]methanol
[2-Butyl-5-chloro-3-[2′-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl]-methanol
[2-Butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
[2-Butyl-4-chloro-1-([4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl)-1H-imidazol-5-yl]methanol

Work with Losartan

Predict the NMR spectrum1H and 13C shifts with multiplicities Make a solutionWhat to weigh for any molarity and volume Check drug-likenessLipinski, Veber and lead-likeness Isotope patternExact mass and the mass spectrum pattern

Stereoisomers, salts and isotopologues

The same compound in another form: other stereochemistry, a salt or hydrate, the free acid or base, or an isotope-labelled version.

Losartan potassium124750-99-8Salt

Similar compounds

Losartan carboxaldehyde114798-36-672 % similar Losartan carboxylic acid124750-92-171 % similar 2-Butyl-4-chloro-1-[[2′-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol133909-99-667 % similar Fimasartan247257-48-353 % similar Olmesartan144689-24-751 % similar Olmesartan lactone impurity849206-43-551 % similar Olmesartan dimer ester impurity1040250-19-845 % similar Candesartan139481-59-744 % similar

Tanimoto similarity of circular fingerprints over the whole catalogue.

All similar compounds

Elsewhere

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