Piperazine

C₄H₁₀N₂CAS 110-85-086.14 g/mol

Open in Covalent MOL file

Secondary amine

Properties

Molecular formula: C₄H₁₀N₂
Molar mass: 86.14 g/mol
Exact mass: 86.0844 Da
Density: 1.1 g/mL
Melting point: 106 °C
Boiling point: 146 °C
pKa: 5.33 (second nitrogen), 9.73 (first nitrogen)
Water solubility: 150 g/L (20 °C)
logP: -0.82Crippen estimate
Polar surface area: 24.1 Å²
H-bond donors / acceptors: 2 / 2
Rotatable bonds: 0

Hazards

Danger

H314 Causes severe skin burns and eye damageSkin corrosion/irritation
H317 May cause an allergic skin reactionSensitization, Skin
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaledSensitization, respiratory
H361fd Suspected of damaging fertility; Suspected of damaging the unborn childReproductive toxicity

Harmonised EU classification (CLP Annex VI, index 612-057-00-4), via PubChem.

Precautionary statements

P203, P233, P260, P261, P264, P271, P272, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P321, P333+P317, P342+P316, P362+P364, P363, P403, P405, P501

Identifiers

CAS number

110-85-0

SMILES

C1CNCCN1

InChIKey

GLUUGHFHXGJENI-UHFFFAOYSA-N

InChI

InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2

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Type any one amount. The others follow from the molar mass and density.

Names and synonyms

18 names · show all

Antiren
1,4-Diazacyclohexane
Diethylenediamine
Dispermine
Hexahydropyrazine
Lumbrical
Piperazidine
Pyrazine, hexahydro-
Pyrazine hexahydride
Pipersol
1,4-Piperazine
Wurmirazin
Worm-A-ton
Eraverm
Uvilon
Vermex
NSC 474
Tetrahydro-1,4-diazine

Safety data sheets

One stored sheet lists this compound in section 3, matched by the CAS number 110-85-0. Each row opens the sheet with its composition and PDF.

Piperazine > 95 %Fisher Scientific · 2025-12-18

Open in the SDS library

Work with Piperazine

Predict the NMR spectrum1H and 13C shifts with multiplicities Make a solutionWhat to weigh for any molarity and volume Check drug-likenessLipinski, Veber and lead-likeness Boiling point under vacuumAt any pressure, from its normal boiling point Isotope patternExact mass and the mass spectrum pattern

Stereoisomers, salts and isotopologues

The same compound in another form: other stereochemistry, a salt or hydrate, the free acid or base, or an isotope-labelled version.

Arpezine142-63-2Hydrate Piperazine citrate144-29-6Salt Piperazine adipate142-88-1Salt Ogen7280-37-7Salt Piperazine hydrochloride142-64-3Salt Piperazine phosphate14538-56-8Salt Piperazine, phosphate (1:?)1951-97-9Salt Niclosamide piperazine salt34892-17-6Salt Piperazine, phosphate, hydrate (1:1:1)18534-18-4Salt Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate41372-10-5Salt

Similar compounds

Aziridine151-56-4100 % similar Cyclen294-90-6100 % similar 1,4,7-Triazacyclononane4730-54-5100 % similar Polyethylenimine9002-98-6100 % similar Cyclen tetrahydrochloride10045-25-767 % similar 1,4,8,12-Tetraazacyclopentadecane15439-16-467 % similar Cyclam295-37-467 % similar 1,4-Diazacycloheptane505-66-867 % similar

Tanimoto similarity of circular fingerprints over the whole catalogue.

All similar compounds

Same formula

(R)-3-Aminopyrrolidine116183-82-5 (-)-3-Aminopyrrolidine128345-57-3 1-Aminopyrrolidine16596-41-1 3-Aminopyrrolidine79286-79-6 Azoethane821-14-7

Elsewhere

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