Tetrahydrofuran

C4H8OCAS 109-99-972.11 g/mol

Open in Covalent MOL file
O
Ether

Properties

Molecular formula
C4H8O
Molar mass
72.11 g/mol
Exact mass
72.0575 Da
Density
0.8892 g/mL (at 20 °C)
Melting point
−108.3 °C
Boiling point
65 °C
pKa
-2.08
Flash point
-14.5 °C (closed cup)
Water solubility
miscible (25 °C)
logP
0.80Crippen estimate
Polar surface area
9.2 Ų
H-bond donors / acceptors
0 / 1
Rotatable bonds
0

Hazards

Danger
Flammable (GHS02)Irritant (GHS07)Health Hazard (GHS08)

Harmonised EU classification (CLP Annex VI, index 603-025-00-0), via PubChem.

Precautionary statements

P203, P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, P501

Identifiers

CAS number
109-99-9
SMILES
C1CCOC1
InChIKey
WYURNTSHIVDZCO-UHFFFAOYSA-N
InChI
InChI=1S/C4H8O/c1-2-4-5-3-1/h1-4H2

Weigh it out

Type any one amount. The others follow from the molar mass and density.

Names and synonyms

11 names
  • Furan, tetrahydro-
  • Butane, 1,4-epoxy-
  • Butane α,δ-oxide
  • Cyclotetramethylene oxide
  • Furanidine
  • Oxacyclopentane
  • Oxolane
  • Tetramethylene oxide
  • THF
  • NSC 57858
  • 2,3,4,5-Tetrahydrofuran

Reactions

Safety data sheets

3 stored sheets list this compound in section 3, matched by the CAS number 109-99-9. Each row opens the sheet with its composition and PDF.

Open in the SDS library

Work with Tetrahydrofuran

Predict the NMR spectrum1H and 13C shifts with multiplicities Make a solutionWhat to weigh for any molarity and volume Check drug-likenessLipinski, Veber and lead-likeness Boiling point under vacuumAt any pressure, from its normal boiling point Isotope patternExact mass and the mass spectrum pattern

Stereoisomers, salts and isotopologues

The same compound in another form: other stereochemistry, a salt or hydrate, the free acid or base, or an isotope-labelled version.

Deuterated thf1693-74-9Labelled Tetrachlorobis(tetrahydrofuran)zirconium21959-01-3Salt

Similar compounds

Tetrahydropyran142-68-789 % similar Oxetane503-30-078 % similar Tetrachlorobis(tetrahydrofuran)titanium31011-57-157 % similar 1,1′-Oxybis[4-chlorobutane]6334-96-957 % similar Pentyl ether693-65-257 % similar 4,9-Dioxa-1,12-dodecanediamine7300-34-757 % similar 1,4-Dioxane123-91-156 % similar 18-Crown-617455-13-956 % similar

Tanimoto similarity of circular fingerprints over the whole catalogue.

All similar compounds

Same formula

1,2-Epoxybutane106-88-7 Ethyl vinyl ether109-92-2 2-Methoxypropene116-11-0 Butyraldehyde123-72-8 cis-2,3-Epoxybutane1758-33-4 trans-2,3-Dimethyloxirane21490-63-1 Poly(ethyl vinyl ether)25104-37-4

Elsewhere

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